1. Sinopol® prescribing information, February 2019.

  2. Bellver J, Rodriguez-Tabernero L, Robles A, Munoz E, Martinez F, Landeras J. et al. Polycystic ovary syndrome throughout a woman's life. J Assist Reprod Genet 2018;35:25–39. Doi: 10.1007/s10815-017-1047-7.

  3. Cappelli V, Musacchio MC, Bulfoni A, Morgante G, De Leo V. Natural molecules for the therapy of hyperandrogenism and metabolic disorders in PCOS. Eur Rev Med Pharmacol Sci 2017; 21(2 Suppl):15-29.

  4. Mohamaddi M. Oxidative Stress and Polycystic Ovary Syndrome: A Brief Review. Int J Prev Med 2019;10:86. Doi: 10.4103/ijpvm.IJPVM_576_17.

  5. Mayo Clinic. Polycystic ovary syndrome (PCOS) [online] [cited December 2022]; Available from:

  6. NHS. Polycystic ovary syndrome. Treatment [online] [cited December 2022]; Available from:,discussed%20in%20more%20detail%20below.

  7. Rago R, Marcucci I, Leto G, Caponecchia L, Salacone P, Bonanni P, et al. Effect of myo-inositol and alpha-lipoic acid on oocyte quality in polycystic ovary syndrome non-obese women undergoing in vitro fertilization: a pilot study. J Biol Regulators Homeostatic Agents 2015;29(4):1-1

  8. Teede HJ, Misso ML, Deeks AA, et al. Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline. Med J Aust. 2011 Sep 19;195(6):S65-112

  9. Deswal R, Narwal V, Dang A, Pundir CS. The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. J Hum Reprod Sci. 2020;13(4):261-271.

  10. NHS. Polycystic ovary syndrome. Causes [online] October 2022 [cited December 2022]; Available from:

  11. Rojas J, Chávez M, Olivar L, et al. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth. Int J Reprod Med. 2014;2014:719050.

  12. Everything You Should Know About Oxidative Stress [online] 2018 [cited December 2022]; Available from:

  13. Ndefo UA, Eaton A, Green MR. Polycystic ovary syndrome: a review of treatment options with a focus on pharmacological approaches. P T. 2013;38(6):336-55.

  14. Polycystic Ovary Syndrome (PCOS) [online] [cited December 2022]; Available from:

  15. Centers for Disease Control and Prevention. PCOS (Polycystic Ovary Syndrome) and Diabetes [online] March 2020 [cited December 2022]; Available from:

  16. NHS. Polycystic ovary syndrome. Overview [online] October 2022 [cited December 2022]; Available from:

  17. Emotional Well-being and PCOS [online] [cited December 2022]; Available from URL:

  18. Williams S, Sheffield D, Knibb RC. The Polycystic Ovary Syndrome Quality of Life scale (PCOSQOL): Development and preliminary validation. Health Psychology Open 2018:1-8. DOI: 10.1177/2055102918788195.

  19. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763.

  20. Villines Z. How do free radicals affect the body? [online] 2017 [cited December 2022]; Available from:

  21. Kumar K. What Does Oxidative Stress Mean? Free Radical Damage [online] 2021 [cited December 2022]; Available from:

  22. MedicineNet. Sugar Detox: Hype or Hope? [online] [cited December 2022]; Available from:

  23. Agarwal A, Aponte-Mellado A, Premkumar BJ, et al. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol 2012;10:49.

  24. Daiber A, Kröller-Schön S, Oelze M, et al. Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitic oxide synthases. Redox Biology 2020;34:101506.

  25. Barber TM, Hanson P, Weickert MO, et al. Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies. Clin Med Insights Reprod Health. 2019;13:1179558119874042

  26. Monash University. Lifestyle and PCOS [online] [cited December 2022]; Available from:

  27. Kanbour SA, Dobs AS. Hyperandrogenism in Women with Polycystic Ovarian Syndrome: Pathophysiology and Controversies.Androgens: Clinical Research and Therapeutics. 2022:22-30.

  28. Victoria State Government. Department of Health. Better Health Channel. Androgen deficiency in women [online] 2022 [cited December 2022]; Available from:

  29. Mayo Clinic. Hirsutism [online] cited December 2022]; Available from:

  30. National Library of Medicine. Medline Plus. Ovarian overproduction of androgens [online] [cited December 2022]; Available from:

  31. Mayo Clinic. Polycystic ovary syndrome (PCOS) [online] [cited December 2022]; Available from:

  32. Genazzani AD, Despini G, Santagni S, et al. Effects of a Combination of Alpha Lipoic Acid and Myo-Inositol on Insulin Dynamics in Overweight/Obese Patients with PCOS. Endocrinol Metab Synd 2014,3(3). DOI: 10.4172/2161-1017.1000140.

  33. Gambera, Visenzi, Fratus, et al. Alternative insulin-sensitizers (Lipoic acid and Inositol) in polycystic ovary syndrome (PCOS). Giorn It Ost Gin (Giornale Italiano di Ostetriciae Ginecologia) 2012; XXXIV(1):182-183.

  34. Carbonelli MG, Di Renzo L, Bigioni M, et al. α-Lipoic Acid Supplementation: A Tool for Obesity Therapy? Curr Pharmaceut Design 2010;16:840-846

  35. Veltman-Verhulst SM, Boivin J, Eijkemans MJC, et al. Emotional distress is a common risk in women with polycystic ovary syndrome: a systematic review and meta-analysis of 28 studies. Human Reproductive Update 2012;18(6):638-651. doi:10.1093/humupd/dms029.
  36. Tay CT, Teede HJ, Hill B, et al. Increased prevalence of eating disorders, low self-esteem, and psychological distress in women with polycystic ovary syndrome: a community-based cohort study. Fertil Steril 2019;112(2):353-361.
  37. Williams S, Sheffield D, Knibb RC. 'Everything's from the inside out with PCOS': Exploring women's experiences of living with polycystic ovary syndrome and co-morbidities through Skype™ interviews. Health Psychology Open 2015:1-10. DOI: 10.1177/2055102915603051.
  38. Iezzi ML, Varriale G, Rorge N, et al. Polycystic ovary syndrome in adolescence: new therapeutic approach with inositol and alpha-lipoic acid. Int J Curr Res 2017;9(7):54006-54011.
  39. De Cicco S, Immediata V, Romualdi D, et al. Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. Gynecol Endocrinol 2017;33(9):698–701.
  40. Gurevich R. HOW TO GET PREGNANT WITH PCOS [online] January 2023 [cited April 2022]; Available from:
  41. Sharif E, Rahman S, Zia Y, Rizk NM. The frequency of polycystic ovary syndrome in young reproductive females in Qatar. Int J Women's Health 2017;9:1-10.
  42. Teede H, Deeks A, Moran L. RPolycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Medicine 2010, 8:41
  43. Barthelmess EK, Naz RK. Polycystic ovary syndrome: current status and future perspective. Front Biosci (Elite Ed). 2014 Jan 1;6:104-19.

Proprietary name (and dosage form): SINOPOL® granules. Composition: Each sachet contains: Myo-inositol 1 000 mg, Alpha Lipoic Acid 400 mg and Folic Acid 200 μg. Complementary Medicine: Health Supplement. D34.12 Multiple Substance formulation. This unregistered medicine has not been evaluated by SAHPRA for its quality, safety or intended use. For full prescribing information, refer to the professional information available at Further information is available on request from iNova Pharmaceuticals. Name and business address of applicant: iNova Pharmaceuticals (Pty) Limited. Co. Reg. No. 1952/001640/07, 15e Riley Road, Bedfordview. Tel. No. 011 087 0000.